Fibrinogen





Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin.

3D Structure of Fibrinogen
Update June 2011

Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (Fba, Fbb , Fbg ).

Fibrinogen α+β+γ chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human

3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B

2xnx, 2xny - hFba+hFbb+hFbg + M1 protein

2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor

1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg

1jy3, 1deq – cFba+cFbb+cFbg – cow

1jy2 - cFba+cFbb+cFbg proteolytic fragment

1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey

1m1j - heFba+heFbb+heFbg+peptide ligand – hen

1ei3 - heFba+heFbb+heFbg

Fibrinogen α chain
1fzd – hFba EC domain

1bbr – hFba+cε-thrombin

2jor – cFba – NMR

2baf – cFba

Fibrinogen β chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand

1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen γ chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus

2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains

2fib, 3fib - hFbg+peptide ligand

1fib – hFbg+Ca

1fic, 1fid – hFbg

3fib – hFbg C terminal

1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum

2hwl – hFbg peptide+prothrombin